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在接受capecitabine的患者中DPYD基因定型:D-TORCH研究的探索性分析

Hemavathi Baskarane1, Mohit Kumar Divakar1, Akhil P Santhosh1

  • 1Department of Medical Oncology, All India Institute of Medical Science, New Delhi, India.

Frontiers in pharmacology
|March 9, 2026
PubMed
概括

印度患者对DPYD变异的基因测试显示,代谢不良的患病率很低,这表明目前的capecitabine毒性查可能需要对特定人群进行调整. 需要进一步的研究来证实这些发现.

关键词:
在 D-TORCH 试验中.在DPYD基因多态化过程中,癌症基因组学 癌症基因组学卡佩西塔的毒性 卡佩西塔的毒性药物基因组学 (PGx) 的研究药物学上的药物学.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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