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在Sintilimab引起的胰腺炎后,成功的免疫检查点抑制剂重新挑战:一个案例报告

Hao Shi¹, Lin Ye¹, Qinrong Mo¹

¹Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Guilin Medical University, Guilin, People's Republic of China.

International medical case reports journal

|March 9, 2026

概括

免疫检查点抑制剂 (ICI) 可以导致晚期肝细胞癌 (HCC) 患者的胰腺炎. 在胰腺炎消失后恢复ICI治疗可以安全地控制癌症并防止复发.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

肝细胞癌 (HCC) 是中国癌症死亡的主要原因.
免疫检查点抑制剂 (ICI) 改善了先进的HCC治疗,但可能导致与免疫相关的不良事件 (irAEs).
免疫检查点抑制剂相关胰腺炎 (ICIPI) 是一种罕见但严重的irAE.

研究的目的:

评估在ICIPI完全消失后恢复ICI治疗的安全性和有效性,在晚期HCC患者中.
在临床实践中建立ICIPI潜在的管理策略.

主要方法:

一个病例报告是一名28岁的患者,患有无法切除的HCC,接受PD-1抑制剂 (sintinilimab) 治疗.
诊断和管理ICIPI.
在胰腺炎解决后恢复使用替代PD-1抑制剂 (tislelizumab) 的免疫治疗.
对瘤反应和ICIPI复发的评估.

主要成果:

患者在辛提尼利马布治疗期间发展了ICIPI.
在ICIPI完全消失后,恢复了用tislelizumab的治疗.
患者在没有ICIPI复发的情况下实现了部分瘤反应.
在随访期间观察到持久的瘤控制.

结论:

在ICIPI完全消失后,恢复ICI治疗用替代药物是可行的.
这一策略可以防止ICIPI复发,并保持抗瘤疗效.
这个案例提供了一个实用的方法来管理ICIPI在先进的HCC患者.

关键词:

案例报告案例报告肝细胞癌是肝细胞癌.免疫检查点抑制剂免疫检查点抑制剂与免疫相关的不良事件.胰腺炎胰腺炎

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