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Updated: Mar 10, 2026

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在甲状腺癌中促进扩散,入侵,迁移和EMT的LncRNA VCAN-AS1海绵miR-374c-3p
Yan Zhang1, Lu Sun1,2, Yuqi Wu3
1Department of Endocrinology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212000, China, ujs.edu.cn.
International journal of endocrinology
|March 9, 2026
概括
长非编码RNA VCAN-AS1 (lncRNA VCAN-AS1) 促进甲状腺癌 (TC) 细胞生长和通过海绵miR-374c-3p.p.传播. 这种lncRNA VCAN-AS1作为竞争的内源RNA,为TC治疗策略提供了新的见解.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 甲状腺癌 (TC) 是全球最常见的内分泌恶性瘤,发病率越来越高.
- 长非编码RNAs (lncRNAs) 在TC病变发生中的作用是一个正在积极研究的领域.
研究的目的:
- 在甲状腺癌细胞中研究lncRNA VCAN-AS1的功能.
- 阐明TC进展中VCAN-AS1的潜在分子机制.
主要方法:
- 在临床TC组织中评估VCAN-AS1表达的LncRNA测序和RT-qPCR.
- 在体外测试 (CCK-8,细胞,Transwell) 和西布洛特测试,以评估VCAN-AS1对TC细胞的影响.
- 生物信息分析,RT-qPCR和双露西法酶测定证实了VCAN-AS1/miR-374c-3p相互作用.
主要成果:
- 与相邻的正常组织相比,TC组织中的VCAN-AS1表达显著上调.
- 过度表达VCAN-AS1增强TC细胞的增殖,迁移和入侵,并促进上皮-介质细胞过渡 (EMT).
- VCAN-AS1通过菌miR-374c-3p作为竞争的内源RNA,从而促进TC进展.
结论:
- 通过调节miR-374c-3p轴,VCAN-AS1在甲状腺癌中起到瘤原发性lncRNA的作用.
- 准VCAN-AS1/miR-374c-3p通路可能为甲状腺癌提供一种新的治疗策略.
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