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相关概念视频

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
289
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
399
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

806
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
806
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

283
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
283
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

639
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
639
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

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Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
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多组分氧化-甲胺盐:朝着增强溶解性和稳定性的战略

Estephany Muñoz-Hernández1,2, Carolina Alarcón-Payer3, Antonio Frontera4

  • 1Laboratorio de Estudios Cristalográficos, IACT-CSIC, Avda. de las Palmeras 4, 18100 Armilla, Spain.

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概括
此摘要是机器生成的。

为了改善药物特性,创造了新的oxicam-metformin盐. 这些药品多元组件材料增强了组合疗法的稳定性和溶解性,提供了一个合理的设计框架.

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科学领域:

  • 材料科学 材料科学 材料科学
  • 制药化学 制药化学 制药化学
  • 固态化学 固态化学

背景情况:

  • 药物药物制药多元组件材料 (PMM) 是调节药物特性和使组合治疗成为可能的关键.
  • 催化剂 (piroxicam, meloxicam,tenoxicam) 是一种非类固醇抗炎药物,具有组合治疗的潜力.
  • 甲胺 (MTF) 是一种广泛使用的抗糖尿病药物.

研究的目的:

  • 为了制备和表征新型氧卡姆-甲 (MTF) 盐.
  • 调查超分子合成子在盐形成和结构-性质关系中的作用.
  • 评估这些盐对药物的稳定性,溶解性和光效应的影响.

主要方法:

  • 合成和完全表征氧卡姆-MTF盐.
  • 对于结构分析的X射线衍射和计算研究.
  • 稳定性,水溶性和光谱分析.

主要成果:

  • 新的oxicam-MTF盐已经成功地准备和表征.
  • 超分子合成子被确定为指导盐形成和影响分子包装的关键.
  • 这些新型盐增强了MTF的稳定性,并保护皮洛克萨姆 (PRX) 免受水化.
  • 加入MTF增加了氧化的溶解度,而盐的形成减轻了MTF的过度溶解度.
  • 由于盐框架内的功能组相互作用,观察到光行为的显著变化.

结论:

  • 这项研究扩大了已知的oxicam-MTF盐的范围.
  • 这些发现为设计具有改善物理化学性质的固体形式提供了合理的基础.
  • 这些PMM为开发增强组合疗法提供了一个有前途的战略.