血清内在系统性红斑狼中:对内皮功能障碍和心血管风险的影响
Aya A El Shintenawy1, Esraa Elshintenawy1, Reem M Awny2
1Department of Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt.
International journal of rheumatic diseases
|March 9, 2026
概括
血清内分泌水平在患有全身性红斑狼 (SLE) 的患者中升高,与疾病持续时间和内皮功能障碍和动脉样硬化标记相关. 这表明内分泌可能在SLE相关的心血管并发症中发挥作用.
科学领域:
- 风湿病学和免疫学
- 心血管研究研究心血管研究
- 生物标志物发现发现
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,其特点是多系统参与.
- 内皮功能障碍是动脉样硬化的早期指标,可能与SLE的发病有关.
- 一种新的内皮功能障碍标志物Endocan可能参与SLE的炎症过程.
研究的目的:
- 为了研究SLE患者的血清内分泌水平.
- 评估血清内分泌与疾病活性,内皮功能障碍和SLE中亚临床动脉样硬化之间的关联.
主要方法:
- 研究了一组60名SLE患者和60名健康对照组.
- 使用SLEDAI评分和通过健康评估问卷 (HAQ) 评估功能状态来评估疾病活动.
- 测量了血清内膜水平,动脉内膜介质厚度 (cIMT) 和臂动脉流媒扩张 (FMD),以评估亚临床动脉样硬化和内皮功能.
主要成果:
- 与对照组相比,SLE患者的血清内分泌细胞水平显著更高.
- 患有SLE的患者表现出增加的cIMT和受损的口病,这表明亚临床动脉样硬化和内皮功能障碍.
- 血清内分泌细胞水平与疾病持续时间,甘油三和cIMT正相关,与口炎负相关.
结论:
- 在SLE患者中血清内分泌水平升高与亚临床动脉样硬化和内皮功能障碍有关.
- 在SLE患者中,Endocan可以作为心血管并发症的潜在生物标志物.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
681
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
681
01:25Endocarditis II: Clinical Features of Infective Endocarditis
668
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
668