怀孕期间阿片类药物依赖的阿片激素治疗趋势:新南威尔士州的一项基于人口的研究2005-2021年
Duong Thuy Tran1, Bianca Varney1,2, Nicola Jones1
1National Drug and Alcohol Research Centre, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.
Drug and alcohol review
|March 9, 2026
概括
怀孕期间的阿片类激素治疗 (OAT) 仍然很常见,甲的使用量下降,布普伦诺芬的使用量增加. 增加布普伦诺芬的使用需要策略,以支持在怀孕期间保持治疗.
科学领域:
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
- 产科 产科 产科 产科 产科
背景情况:
- 怀孕期间的阿片类药物依赖对父母和孩子都带来了重大挑战.
- 片激动剂治疗 (OAT) 是孕期阿片类药物依赖的标准护理.
- 了解OAT类型的趋势和怀孕期间的变化对于优化护理至关重要.
研究的目的:
- 检查怀孕期间OAT的趋势.
- 分析OAT类型 (甲与布普伦诺啡) 随时间的变化.
- 调查怀孕期间OAT类型变化的发生和模式.
主要方法:
- 一项数据链接研究在澳大利亚新南威尔士州进行.
- 该队列包括2005年至2021年间导致分娩的怀孕.
- 计算了OAT的患病率,OAT类型,以及怀孕期间OAT类型的变化.
主要成果:
- 在5212个怀孕中,78.7%的孕妇接受了OAT.
- 年度OAT患病率保持稳定,但甲使用量下降 (70.9%至37.4%),而布普伦诺芬使用量增加 (12.3%至29.3%).
- 在5.5%的怀孕中发生了OAT类型的变化,随着时间的推移,从布普伦诺芬到美沙的比例正在下降.
结论:
- 怀孕期间OAT是普遍和稳定的,但治疗成分正在转向布普伦诺芬.
- 怀孕期间增加布普伦诺芬的使用值得注意,因为可能会有更高的断药率.
- 需要有针对性的策略,以确保怀孕期间OAT患者的治疗持续.
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