在患有肠道衰竭的儿科患者中,比较碳酸和乙醇用于中央线路锁定
Kate McNevin1, Beatrice E Rosete2, Shiho Fukasawa2
1Division of Pediatric General and Thoracic Surgery, Seattle Children's Hospital, Seattle, Washington, USA.
Journal of pediatric gastroenterology and nutrition
|March 9, 2026
概括
碳酸锁是一种安全有效的替代乙醇锁,用于预防患有肠道衰竭的儿童中中枢线相关血流感染 (CLABSI). 这一战略还减少了线路更换和维修.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 预防传染病 预防传染病
- 血管接入管理系统
背景情况:
- 患有肠衰竭 (IF) 的儿童需要中央静脉导管 (CVC) 来进行腹腔营养,增加他们患中枢线相关血流感染 (CLABSI) 的风险.
- 乙醇锁治疗一直是这些患者预防CLABSI的标准预防措施.
- 全国乙醇短缺促使人们研究替代锁定解决方案,特别是二碳酸.
研究的目的:
- 评估与乙醇锁相比,二碳酸锁在预防FI的儿科患者中CLABSI的疗效.
- 评估这些锁定解决方案对CVC维修和更换率的影响.
主要方法:
- 一项回顾性队列研究分析了患有FI的儿科患者 (0-21岁),他们在2018年至2023年期间接受过乙醇或碳酸锁.
- CLABSI,线路修复,线路更换和线路封闭率是每1000个导管天计算的.
- 乙醇和二碳酸组之间的统计比较使用曼-惠特尼U或费舍尔的精确测试进行.
主要成果:
- 该研究包括55名患者:19名患者在乙醇组,36名患者在二碳酸组.
- 这两组的CLABSI率是可比的 (2.03对1.59每1000个导管天,p=0.617).
- 碳酸组显示线路更换率明显较低 (p=0.01) 和线路维修率较低的趋势 (p=0.23).
结论:
- 碳酸锁是一种安全有效的替代乙醇锁,用于预防儿科FI患者的CLABSI.
- 这种替代策略与相应的CLABSI率和减少CVC操纵 (更换和维修) 相联系.
- 在乙醇短缺期间,碳酸为维持CVC完整性和患者安全提供了可行的解决方案.
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