纳米酶催化恢复毛囊完整性,通过逆转氧体崩
Songling Jiang1, Jemin Choi2, Seungho Jeon2
1Integrated Omics Institute, Wonkwang University, Jeonbuk State, Iksan 54538, South Korea.
ACS nano
|March 9, 2026
概括
过氧体功能障碍通过破坏新陈代谢和增加氧化应激导致脱发. 针对过氧体的新型纳米酶促进毛囊再生,为脱发症提供了一种新的治疗方法.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 皮肤病学 皮肤病学
背景情况:
- 线粒体缺陷是已知导致脱发的原因.
- 过氧体功能障碍在毛囊衰老和脱发症中的作用在很大程度上是未被探索的.
研究的目的:
- 调查过氧体功能障碍在毛囊老化和脱发症中的作用.
- 探索以纳米酶为基础的治疗策略,通过准过氧体功能来治疗脱发.
主要方法:
- 从脱毛患者身上获得的人体皮肤乳头细胞的转录组分析.
- 对Nudt7缺乏的小鼠进行分析,这些小鼠的过氧体脂质代谢受损.
- 开发和测试模仿催化酶活性的催化纳米酶 (HA-Hem).
- 在小鼠模型中评估纳米酶对毛囊再生,氧化应激和代谢途径的影响.
- 空间转录基因分析用于评估再生计划.
主要成果:
- 脱发症患者表现出下调的过氧体相关途径.
- 缺少Nudt7的小鼠表现出头发变薄,卵泡缩小以及由于过氧体功能障碍而增加的氧化应激.
- 纳米酶治疗恢复了新陈代谢平衡,减少了氧化损伤,并刺激了毛囊再生.
- 纳米酶增强了PPARα的表达,促进了过氧体生物发生和脂质代谢,并改善了过氧体-线粒体相互作用.
- 与米诺西迪尔相比,纳米酶治疗显示出更好的再生反应,特别是在免疫缺陷模型中.
结论:
- 过氧体功能障碍是毛囊衰老和脱发的关键因素.
- 用纳米酶向过氧体功能代表了治疗脱毛症的一个有前途的治疗策略.
- 通过过氧体增强恢复新陈代谢和氧化还原平衡,促进毛囊再生.
关键词:
毛囊再生 毛囊再生脱发 脱发 脱发 脱发 脱发 脱发 脱发 脱发 脱发纳米酶纳米酶是一种纳米酶.过氧酶体功能障碍是什么有活性氧物种的反应性氧物种.氧化还原稳态 (redox homeostasis) 是一种反氧化稳态.空间转录学 空间转录学更多相关视频
10:05Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
Published on: May 8, 2020
2.3K
06:41A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
Published on: March 9, 2015
9.5K
相关概念视频
01:06Multipotency and Niche of Bulge Stem Cell
4.3K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
4.3K
01:20Accessory Structures of the Skin: Hair Growth and Types
2.8K
Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
2.8K
02:37Restarting Stalled Replication Forks
6.5K
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
6.5K
01:38Nucleotide Excision Repair
5.5K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.5K
01:15Neurogenesis and Regeneration of Nervous Tissue
1.9K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.9K