洛萨尔坦对预防乳腺癌中帕克利塔塞尔诱导的外周神经病变的影响:一项随机对照研究
Aalaa Mahmoud Ahmed Shawqi Mahmoud1, Emad Shash2, Hayam Ateyya1
1Department of Pharmacy Practice and Clinical Pharmacy, Faculty of Pharmacy, Future University in Egypt, Cairo, Egypt.
Pharmacotherapy
|March 9, 2026
概括
洛萨坦显著减少和延迟乳腺癌患者的帕克利塔塞尔诱导的周围神经病变 (PIPN). 这项研究表明,洛萨坦可以作为PIPN的潜在预防剂,改善患者的生活质量并减少疼痛.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 帕克利塔塞尔诱导的周围神经病变 (PIPN) 是化疗的常见和持续的副作用.
- 目前,对于PIPN.目前还没有经过证明的预防性治疗方法.
- 临床前研究表明,洛萨坦可以提供神经保护,防止神经受伤.
研究的目的:
- 评估洛萨坦对乳腺癌患者PIPN的神经保护作用.
- 评估洛萨坦在预防或延迟化疗诱导的神经病变的开始方面的疗效.
主要方法:
- 一个单中心,开放标签,随机对照试验,涉及早期乳腺癌妇女,计划接受帕克利塔塞尔化疗.
- 参与者被随机分配,接受洛萨坦 (每天100毫克) 加标准护理或单独标准护理.
- 主要终点:第二级或更高神经病变的发生率 (NCI-CTCAE v5.0). 二级终点包括生活质量,疼痛强度和血清神经生长因子 (NGF) 水平.
主要成果:
- 洛萨坦显著降低了≥2级神经病变的发生率 (33.3%与86.4%,p<0.001),并延迟了其发病 (73.27与43.75天).
- 与对照组相比,接受洛萨坦的患者报告生活质量更好 (FACT/GOG-NTX得分) 和疼痛减少 (VAS得分).
- 血清NGF水平和不良事件在洛萨坦和对照组之间是可比的.
结论:
- 每日服用洛沙坦有效地减少和延迟了临床上显著的帕克利塔塞尔诱导的神经病变.
- 洛萨坦改善了患者报告的结果,包括生活质量和疼痛减轻,而不会增加毒性.
- 支持将洛萨坦作为PIPN的低成本预防药物,这需要在更大规模的试验中进一步调查.
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