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针对HSV糖蛋白B的抗体需要效应器功能来保护新生小鼠

Matthew D Slein^1,2, Lesle M Jiménez^1,2, Iara M Backes^1,2

¹Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.

Journal of virology

|March 9, 2026

概括

针对简单疹病毒 (HSV) 糖蛋白B (gB) 的单克隆抗体保护新生儿免受HSV感染. Fc效应器功能对于这种保护至关重要,它为新型HSV疫苗和抗体疗法的设计提供了信息.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
疫苗学疫苗学疫苗学

背景情况:

简单疹病毒 (HSV) 感染构成重大威胁,特别是在新生儿身上.
糖蛋白B (gB) 对于HSV进入宿主细胞至关重要,是免疫反应的关键标.
单克隆抗体 (mAbs) 正在被探索作为治疗和预防病毒感染的药物,包括HSV.

研究的目的:

在小鼠模型中研究gB特异性单克隆抗体 (mAbs) 对新生儿HSV (nHSV) 感染的保护机制.
确定病毒中和和Fc效应函数在mAb介导保护中的相对贡献.
评估使用腺相关病毒 (AAV) 介导的体内抗体表达的跨代保护潜力.

主要方法:

利用新生儿HSV感染的小鼠模型.
在不同的剂量中使用一组gB特定的mAbs.
评估了mAbs.的病毒中和和Fc效应器功能.
使用AAV介导的gB特异性mAb体内表达来评估跨代保护.

主要成果:

对nHSV死亡率的单克隆抗体介导保护依赖于剂量和Fc效应函数,后者是关键的.
病毒中和有助于保护,但不是唯一或主要的机制.
对HSV-1和HSV-2死亡率的跨代保护是通过AAV介导的gB特异性mAb的体内表达实现的.

结论:

针对gB的单克隆抗体是治疗HSV感染的有效疗法.
最佳保护需要多样化的抗体功能配置文件,包括Fc效应器功能,而不仅仅是病毒中和.
这些发现对设计有效的HSV疫苗和基于抗体的疗法有重大影响.

关键词:

抗体是一种抗体.效应器的功能是效应器的功能.疹病毒病毒的病毒.这是一个机制机制.新生儿新生儿新生儿新生儿中和化中和化中和化

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