在各种储存条件下,衍生物化合物的稳定性和转化产物
Phillip Berger1,2, Katherine Poisson1,2, Jaime Adams1,3
1Department of Chemistry and Chemical Biology, College of Science, Northeastern University, Boston, MA, USA. z.tian@northeastern.edu.
衍生化合物 (RDCs) 随着时间的推移而降解. 在-20°C的甲醇是储存RDC的最佳溶剂,而酸化水是最不稳定的,影响环境分析.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 化学稳定性 化学稳定性
背景情况:
- 衍生化合物 (RDCs) 给环境带来了挑战.
- RDCs可以转换,使准确的量化变得复杂.
- 由于RDC的不稳定性,采样后直接分析通常是必要的.
研究的目的:
- 在各种储存条件下评估31个RDC的长期稳定性.
- 为了确定RDC样本存储的最佳溶剂和温度.
- 调查RDC转化途径和降解产品.
主要方法:
- 在31个RDC混合物中使用23个标准进行了稳定性研究.
- 样品被存储在不同的溶剂和三个温度点 (-20°C,环境,40°C).
- 使用高分辨率质谱法 (HRMS) 来识别降解产物和变化.
主要成果:
- 甲醇在-20°C被证明是RDC存储最有效的溶剂.
- 酸性脱离离子水是最不稳定的溶剂,导致大量的化合物损失.
- 在相关度下,谷氨并没有阻止PPD转化.
- 六种化合物经历了转化,包括分解和形成新的化合物,如2,4-二甲基基诺.
- 化合物间反应,而不是溶剂降解,是MBT损失的原因.
- 对31种标准混合物的HRMS分析发现了91种独特特征,可能来自RDC相互作用.
结论:
- 样品储存条件对衍生物化合物的稳定性产生重大影响.
- 建议在-20°C的甲醇保持RDC的完整性.
- 了解RDC转型对于准确的环境监测和风险评估至关重要.
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