在美国痴呆症临床试验研究中报告高风险群体:系统性审查
Judith Neugroschl1, Margaret Sewell1, Carolyn Zhu1
1Icahn School of Medicine at Mount Sinai, Alzheimer's Disease Research Center, New York, NY, USA.
Journal of Alzheimer's disease : JAD
|March 9, 2026
概括
在阿尔茨海默病和相关痴呆症临床试验中,关于种族和种族的报道仍然不一致,少数群体的代表性很低. 标准化报告和包容性招聘对于公平的痴呆症研究至关重要.
科学领域:
- 临床试验 临床试验
- 神经科学是一个神经科学.
- 健康差异 在健康上的差异
背景情况:
- 阿尔茨海默氏症和相关痴呆症 (AD/ADRD) 不成比例地影响美国的黑人和西班牙裔人口.
- 这些高风险群体在AD/ADRD随机对照试验 (RCT) 中代表性不足.
- 准确的报告和代表对于了解疾病机制和治疗疗效至关重要.
研究的目的:
- 系统地审查基于美国的AD/ADRDRCT (2010-2023年).
- 评估种族和种族报告的趋势.
- 检查报告和研究特征与少数群体代表性之间的关联.
主要方法:
- 2010-2023年期间在美国进行的AD/ADRDRCT的系统审查.
- 根据PRISMA指南搜索了MEDLINE和Embase数据库.
- 从126个符合条件的试验中提取了研究设计,规模,资金,试验阶段和种族/种族报告的数据.
主要成果:
- 35.7%的试验没有报告种族或种族.
- 在报告试验中,格式各不相同,分类不一致,少数民族代表性低 (白人参与者:71.2-93.3%).
- 较大,多地点,行业资助和药理学试验更有可能报告种族/种族 (p<0.05);没有观察到随着时间的推移而有所改善.
结论:
- 在AD/ADRD可预测试验中,种族和民族的不一致报告仍然存在.
- 在这些关键的临床试验中,少数群体的代表仍然不足.
- 标准化报告和包容性招聘策略是公平的痴呆症研究和护理所必需的.
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