唾液蛋白学揭示了电子烟使用者的氧化标记物
Natalia de Carvalho Faria1, Bruna Fernandes do Carmo Carvalho1, Monica Ghislaine Oliveira Alves1
1Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, São José dos Campos, São Paulo State University (UNESP), São José dos Campos, São Paulo 12245-000, Brazil.
Journal of proteome research
|March 9, 2026
概括
电子烟 (e-cig) 的使用改变了唾液蛋白质配置,增加了参与应激反应和上皮细胞变化的蛋白质. 这突显了潜在的口腔健康风险和需要对用户进行监测.
科学领域:
- 口腔生物学 口腔生物学
- 蛋白质组学是指蛋白质组学.
- 毒理学 毒理学 毒理学
背景情况:
- 电子烟 (e-cigs) 越来越受欢迎,特别是在年轻人中.
- 有关电子烟气溶暴露对口腔的健康影响存在担忧.
研究的目的:
- 研究专用电子烟使用者的唾液蛋白质组.
- 为了识别由于使用电子烟而导致的唾液中的特定蛋白质变化.
主要方法:
- 对比了25名专用电子烟使用者 (EG) 和25名非吸烟者/非使用者 (CG) 的唾液蛋白.
- 在未受刺激的唾液样本上使用蛋白质组分析.
- 应用威尔科克森-曼-惠特尼测试用于差异蛋白质丰度分析.
主要成果:
- 总共确定了1773种蛋白质;92种显示一致的定量值.
- 在不同组中发现了22种不同丰富的蛋白质 (p ≤0.05),在电子烟使用者中最多.
- 值得注意的上调蛋白质:百氧化-1.
- 功能分析表明与化,细胞分化和应激反应相关的途径.
结论:
- 电子烟气溶暴露会在口腔环境中引起显著的生物变化.
- 唾液蛋白质的变化表明细胞防御机制的激活和对上皮质完整性的潜在影响.
- 调查结果强调需要对电子烟用户进行长期监测,并对相关风险进行公共卫生教育.
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