在无症状个体中,胰腺囊的患病率和基于大小的风险分类,并进行MRI查
Paul Wong1, Tommaso Pollini1, Sophia Hernandez1
1Division of Surgical Oncology, Department of Surgery, University of California, San Francisco, San Francisco.
JAMA network open
|March 9, 2026
概括
胰腺囊性病变 (PCL) 很常见,影响6.3%的无症状个体,患病率随着年龄的增长而显著增加. 大多数PCL是小的,但已确定了诸如年龄较大和胰腺癌家族史等风险因素.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 胰腺囊性病变 (PCL) 是胰腺癌的前体,但其在一般人群中的患病率和风险因素尚不清楚.
- 目前切除的指导方针侧重于囊大小和高风险特征,通常基于症状患者的数据.
研究的目的:
- 为了确定PCL在无症状的北美队列中的患病率.
- 根据基于大小的风险对PCL进行分类.
- 确定与PCL发展相关的人口因素和暴露.
主要方法:
- 一项横截面研究分析了从21,651个无症状个体接受全身MRI查的数据.
- 放射科医生使用标准化模板解释扫描,并为PCL分析自由文本报告.
- 数据包括参与者的人口统计和生活方式暴露.
主要成果:
- PCL的患病率为6.3% (根据年龄和性别标准化),随着年龄的增长而增加,在80岁或以上的个人中达到20.8%.
- 大多数PCL (96.0%) 小于2厘米;只有1.1%为3厘米或更大.
- 独立的风险因素包括年龄 (≥65岁),女性性别,胰腺炎或胰腺癌史,胰腺癌家族史,酒精消费和某些种族.
结论:
- 偶然的PCL在无症状个体中很常见,特别是老年人.
- 大多数发现的PCL是小的,可能是低风险的.
- 确定年龄,性别,个人/家庭史和种族等风险因素对于风险分层至关重要.
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