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相关概念视频

Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

5.6K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
5.6K
X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

5.0K
X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
5.0K
Determination of Crystal Structures01:29

Determination of Crystal Structures

30
In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...
30

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相关实验视频

Updated: Mar 11, 2026

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
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On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

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在生物分子结晶的技术尺度.

Wenqing Tian1, Wenqian Chen2, Huaiyu Yang3

  • 1Astrazeneca, Macclesfield, UK.

Advances in biochemical engineering/biotechnology
|March 9, 2026
PubMed
概括
此摘要是机器生成的。

生物分子结晶缩放对于提高产品质量和降低成本至关重要. 本综述涵盖了从纳米升到升尺度的方法,对于工业应用至关重要.

关键词:
生物分子结晶的过程运动动力学 运动动力学 运动动力学微观方法就是宏观方法.过程分析工具 过程分析工具蛋白质蛋白质是一种蛋白质.扩大规模 扩大规模

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Microcrystallography of Protein Crystals and In Cellulo Diffraction
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Microcrystallography of Protein Crystals and In Cellulo Diffraction

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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering

Published on: August 14, 2018

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相关实验视频

Last Updated: Mar 11, 2026

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
07:42

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

2.4K
Microcrystallography of Protein Crystals and In Cellulo Diffraction
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Microcrystallography of Protein Crystals and In Cellulo Diffraction

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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
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科学领域:

  • 生物化学 生物化学
  • 化学工程是化学工程的重要组成部分.
  • 晶体学 晶体学是指结晶学.

背景情况:

  • 生物分子结晶比传统净化提供了优势,但缺乏既定的理论.
  • 蛋白质晶体很脆弱,对环境条件很敏感,与小分子不同.
  • 目前的研究往往侧重于小规模,阻碍了工业应用.

研究的目的:

  • 总结生物分子结晶方法在各种尺度.
  • 审查从微型到大型工艺的扩展机制.
  • 探索结晶运动的过程监测和分析技术.

主要方法:

  • 对生物分子结晶技术的现有文献进行审查.
  • 从纳米升 (nL) 到微升 (μL) 的尺度 (例如,挂/坐滴) 的缩放分析.
  • 检查缩放到毫升 (mL) 和升 (L) 的尺度 (例如批量,微流体,结晶器).

主要成果:

  • 生物分子结晶的方法与尺度有很大差异,从nL到L.
  • 由于蛋白质的复杂性和脆弱性,扩大规模需要适应的技术.
  • 在每个规模上,过程监控和分析方法都至关重要.

结论:

  • 了解扩展机制对于广泛的生物分子结晶至关重要.
  • 有一系列的方法和分析工具可用于不同的尺度.
  • 为了提高工业可行性,需要对规模特定优化的进一步研究.