多发性硬化症患者自我报告的认知问题与基于表现的认知功能障碍之间的非线性关系:一个横截面研究
David E Freedman1,2, Ralph H B Benedict3, Jiwon Oh4,5
1Department of Psychiatry, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada. david.freedman@sunnybrook.ca.
Journal of neurology
|March 9, 2026
概括
多发性硬化症 (pwMS) 患者的自我报告认知问题 (SCC) 预测认知障碍仅在特定值以上. 这一发现凸显了在评估多发性硬化患者时考虑主观认知问题的严重程度的重要性.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 心理学 心理学 心理学
背景情况:
- 自我报告的认知问题 (SCC) 在患有多发性硬化症 (pwMS) 的人中显示出与客观认知功能障碍的弱和不一致的关系.
- 了解这种关系对于准确评估pwMS认知健康至关重要.
研究的目的:
- 在pwMS中调查SCC和客观测量的认知障碍之间的潜在非线性关系.
- 确定SCC预测认知障碍的关键值.
主要方法:
- 933名pwMS的队列完成了MS认知功能的最小评估 (MACFIMS) 和SCC的感知缺陷问卷 (PDQ).
- 认知障碍被定义为≥3个MACFIMS评分≥1.5 SD低于规范数据.
- 用细分后勤回归来分析PDQ得分与认知障碍之间的关联,控制共变量.
主要成果:
- 在46.73%的参与者中存在认知障碍.
- 50或更高的PDQ得分独立地与认知障碍的几率增加有关 (OR=1.92).
- 低于50的PDQ得分与认知障碍没有显著关联 (OR=1.03).
结论:
- 对于SCC,存在一个关键值,超过这个值,患有多发性硬化症的个体具有显著更高的认知障碍的几率.
- 这些发现表明,主观认知问题的严重程度是预测pwMS客观认知缺陷的关键因素.
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