人类和动物模型中心力衰竭后身体活动的变化:范围审查
Akinori Kaneguchi1, Mahiro Fukunaga2, Takuya Umehara2
1Department of Rehabilitation, Faculty of Rehabilitation, Hiroshima International University, Kurose-Gakuendai 555-36, Higashi-Hiroshima, Hiroshima, Japan. a-kanegu@hirokoku-u.ac.jp.
Current heart failure reports
|March 9, 2026
概括
患有心力衰竭 (HF) 的患者表现出体力活动 (PA) 的减少. 肝炎的动物模型并不能始终复制这种PA下降,这凸显了人类肝炎理解临床前研究的局限性.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 翻译医学是一种翻译医学.
背景情况:
- 由于症状和其他因素,心力衰竭 (HF) 患者体验到身体活动 (PA) 减少.
- 这种PA的下降会使身体功能和预后恶化.
- 由于HF和其在动物模型中的复制而导致的PA减少的程度尚不清楚.
研究的目的:
- 为了检查HF患者与非HF对照患者的PA变化.
- 在HF的动物模型中评估PA变化.
- 确定导致人类和动物对高频响应的PA反应差异的因素.
主要方法:
- 对25项人类和20项动物研究进行范围审查.
- 人类研究使用客观评估 (加速计,双标水,计步器) 和问卷.
- 动物研究检查了不同HF病因和物种的PA.
主要成果:
- 客观评估始终表明,在人类HF门诊患者中,PA降低.
- 在人类中基于问卷的PA评估是可变的.
- 不到一半的动物研究报告了降低PA;结果因HF模型和物种而异.
结论:
- 在人类HF患者中,PA持续降低,但在动物模型中不可靠.
- 这些差异表明HF PA研究的临床前模型存在局限性.
- 纳入行为和环境因素对于提高高频研究的翻译相关性至关重要.
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