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便样本的新陈代谢分析揭示了与疾病表型和克罗恩病的位置相关的独特特征

Tingyi Tan¹, Matthew Vincent¹, Umang Jain²

¹Division of Gastroenterology, John T. Milliken Department of Medicine, Washington University School of Medicine, 660 Euclid Avenue, St. Louis, MO, USA.

Digestive diseases and sciences

|March 9, 2026

概括

对克罗恩氏病 (CD) 便样本的代谢分析揭示了与疾病位置,表型和活性相关的不同代谢物概况. 这些发现为风险分层和个性化CD管理提供了潜在的非侵入性生物标志物.

科学领域:

胃肠病学胃肠病学
代谢学代谢学代谢学
炎症性肠道疾病研究研究

背景情况:

克罗恩氏病 (CD) 是一种复杂的炎症状况,根据位置和表型,其临床表现各异.
了解这些变异的分子基础对于有效的患者管理至关重要.
目前对CD亚型之间代谢差异的知识有限.

研究的目的:

在克罗恩病中识别与疾病活性,位置和表型相关的特定代谢物.
探索代谢学在非侵入性风险分层和量身定制的治疗策略方面的潜力.

主要方法:

超高性能液体色谱-并联质谱 (UHPLC-MS/MS) 用于对302名CD患者的便样本进行代谢分析.
活性CD被定义为便calprotectin水平>100μg/g.
统计分析包括对方差的多变量分析和多变量线性模型与错误发现率校正.

主要成果:

复杂性CD表型 (B2/B3) 与炎症性 (B1) 表型相比,显示了甲和二次胆酸的升高.
阴道和阴道结肠CD表现出高水平的胆酸盐和N-乙醇胺比结肠CD.
活跃性疾病与甲基素,胺,米林和多氨酸的增加有关.

结论:

不同的代谢概况与克罗恩病的表型,位置和活动水平相关.
这些已识别的代谢物代表了预测并发症和指导个性化治疗方法的潜在的非侵入性生物标志物.
建议在更大的患者队伍中进一步验证.

关键词:

生物标志物生物标志物克罗恩氏病是什么克罗恩氏病是什么便中的代谢组分.

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