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不同的BLA电路编排了旁观者男性小鼠的社会偏好动态,这些小鼠有自我经历的压力

Xue-Ke Yang¹, Yu-Long Shi¹, Ming Li¹

¹Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, People's Republic of China.

Proceedings of the National Academy of Sciences of the United States of America

|March 9, 2026

概括

社会失败的压力塑造了底侧杏仁体 (BLA) 中的记忆瘤细胞,影响了社会偏好和回避. 这些BLA细胞 (BLA^EC) 对于社会行为至关重要,并与前带皮层 (ACC) 连接.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
分子神经科学分子神经科学

背景情况:

个人经历被编码在记忆引擎细胞中,影响未来的社会互动.
压力后社会偏好动态背后的精确神经回路尚不清楚.

研究的目的:

调查底侧杏仁体瘤细胞 (BLA^EC) 在社会偏好和社会失败后避免压力的作用.
将源自BLA^EC的神经电路映射出来,该电路调节社会行为.

主要方法:

开发了一种小鼠模型,将自我和代理社会失败压力结合起来.
利用化学遗传学来操纵BLA^EC活动.
采用基于病毒的细胞类型特定的大脑映射来追踪预测.

主要成果:

BLA^EC激活与社会偏好和回避行为有显著的相关性.
化学遗传学操纵证实了BLA^EC对这些行为的必要性和充分性.
BLA^EC向前带带皮层 (ACC) 投射,这些投射调节社会动态. 其他预测影响着不同的社会行为.

结论:

来自BLA^EC的分离电路调节了社会偏好动态.
这些发现提供了对社会精神病理学背后的神经生物学机制的见解.

关键词:

基本侧面的杏仁体英格拉姆细胞是什么?神经电路的神经电路.自我体验的自我体验.社会偏好动态的动态.

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