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在成年类型的扩散性结质瘤中,CDKN2A/B和MTAP缺失的关联

Blake A Ebner1, Cristiane M Ida1, Thomas M Kollmeyer

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota USA.

Journal of neuropathology and experimental neurology
|March 9, 2026
PubMed
概括

成人类型扩散性结质瘤的遗传分析显示,CDKN2A/B和MTAP的删除经常同时发生. 较大的9p损失导致并发的异合性缺失,但较小的缺失可能会导致不一致的副本数量,影响作为替代标记物的MTAP免疫组织化学.

关键词:
CDKN2A/B; 质母细胞瘤; 质母细胞瘤MTAP; 寡质质细胞; 寡质质细胞成人类型的扩散性质瘤星系细胞瘤是一个星系细胞瘤.同卵同胞的删除.

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