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工程生物合成气囊用于双模式超声波/NIR-II成像

Qian Zhang^1,2,3,4, Bingtao Ren^1,2,3,4, Yijun Lu^2,3,4

¹Key Laboratory of Biodiversity and Environment on the Qinghai-Tibetan Plateau, Ministry of Education, School of Ecology and Environment, Xizang University, Lhasa 850000, China.

Analytical chemistry

|March 9, 2026

概括

研究人员通过工程气体囊泡 (GVs) 与RGD准和近红外II (NIR-II) 光体开发了一种双模纳米探针. 这种有针对性的方法增强了使用超声波和NIR-II光两种方法的固体瘤成像.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
医疗成像医学成像

背景情况:

气囊 (GVs) 是基因编码的超声波对比剂.
目前的GV缺乏瘤向特异性和多模式成像能力,限制了它们的临床实用性.

研究的目的:

设计具有RGD显示的GV与近红外II (NIR-II) 光体 (CH1055) 集成,用于双模超声波/NIR-II成像.
为了评估新的CH1055@GVs-RGD纳米探针的向瘤积累和成像性能.

主要方法:

用基因和化学修饰来使GVs具有RGD和CH1055的功能.
在体外研究中评估了U87 MG细胞和3D瘤球体的细胞吸收率.
在体内研究评估了超声波和NIR-II光信号在瘤载体模型的瘤口服和静脉注射后.

主要成果:

设计的CH1055@GVs-RGD保持了本地GVs的声学特性.
在体外观察到有效的细胞和球体吸收.
在体内,纳米探针显示持续的超声波和NIR-II信号,与对照组相比,通过RGD介导向显著增强瘤积累.

结论:

基因和化学编程的CH1055@GVs-RGD纳米探针是一种新型的针对性双模态对比剂.
这种双模态方法提供了对固体瘤的高效和特定成像.
针对RGD的策略显著改善了瘤积累,提高了诊断潜力.

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