高负载的氨酸溶解微针,用于儿童友好的皮肤和通过皮肤输送多克西环素
Heba Y Raslan1, Mostafa K Mohammad2, Asmaa M Nasr3
1Institute for Drug Research, Development and Innovation, Assiut University, Assiut 71526, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
International journal of pharmaceutics
|March 9, 2026
概括
氨酸溶解微针 (DMNs) 提供了一种儿童友好的方式来输送多西环素 (DX),改善儿科感染的坚持和疗效. 这个创新的平台可以提高药物输送和患者的治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 制药技术 制药技术 制药技术
- 儿科医学 儿科医学
背景情况:
- 儿科多西环林的输送面临着副作用和不良坚持的挑战.
- 溶解微针 (DMN) 提供了一种最小侵入性的替代方案,但儿科应用尚未得到充分发展.
研究的目的:
- 开发和优化基于氨酸 (HA) 的DMN阵列,用于儿科皮肤输送多西环素 (DX).
- 评估用于儿科的DX载荷DMN (DX-MN) 的安全性,有效性和稳定性.
主要方法:
- 基于HA的DMN被制定和特征 (SEM,DSC,FTIR) 机械性能和溶解.
- 在小鼠模型中评估了抗菌疗效,ex vivo皮肤透,以及in vivo生物相容性/治疗疗效.
- 稳定性研究是按照ICH指南进行的.
主要成果:
- 优化的DX-MN显示了高药物负载 (~99%),快速溶解 (<90s) 和双相透 (~97.5%超过36小时).
- 在体内,DX-MNs保留了抗菌活性,并显示出明显的伤口收缩 (~99%).
- 这些DMN的耐受性很好,稳定 (>95%恢复6个月),并显示出系统性暴露的证据.
结论:
- 氨酸DMN提供了一个安全,有效和儿童友好的平台,用于儿科多西环林的输送.
- 这项技术克服了传统的输送障碍,支持局部和全身抗生素的管理.
- 儿童传染病病毒显示出显著的翻译潜力,可以改善儿科传染病治疗结果.
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