微生物在发酵传统中医药中的应用:一篇评论
Yayuan Li1, Xuanqi Ke1, Zixuan Shu1
1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China.
Journal of ethnopharmacology
|March 9, 2026
概括
微生物发酵通过提高活性成分的溶解性,生物可用性和安全性来增强传统中国医学 (TCM). 本综述综合了关于发酵机制,过程和应用的研究,突出了其在健康和医学方面的潜力.
科学领域:
- 生物技术和传统医学
- 药理学和微生物学 药理学和微生物学
背景情况:
- 微生物发酵对中国传统医学 (TCM) 至关重要,它转化生物活性成分以提高溶解性,生物可用性和减少毒性.
- 尽管有好处,但挑战仍然存在,例如不一致的结果,污染风险和新型代谢物不具特征的安全性.
研究的目的:
- 系统地审查TCM中的微生物发酵,重点关注分子机制,先进的策略和工业应用.
- 整合来自体外,体内和人体研究的证据,解决了解微生物-TCM相互作用和可扩展性的差距.
主要方法:
- 在谷歌学者和PubMed.com等数据库中进行全面的文献搜索.
- 包含关于TCM微生物发酵的同行评审研究,具有明确的菌株,过程和成分有效性数据.
- 不包括未经同行评审的文献和设计不清楚或与微生物发酵无关的研究.
主要成果:
- 功能性微生物转化TCM组件,产生可吸收的分子,更少的有毒衍生物和新的生物活性化合物.
- 发酵增强了TCM的有效性和安全性,通过体外,体外和初步人类研究得到验证.
- 在健康食品和医药领域具有广泛的应用潜力,尽管微生物-TCM相互作用和标准化需要进一步研究.
结论:
- 微生物发酵显著优化了TCM的质量,提高了疗效,降低了毒性,并扩大了应用.
- 未来的研究应该专注于多主题的相互作用研究,过程标准化和探索新型微生物资源.
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