血清和美国退伍军人心力衰竭的结果
Ying Yin1, Charity J Morgan2, Rebecca B Costello3
1Veterans Affairs Medical Center, Washington, DC; George Washington University, Washington, DC.
The American journal of medicine
|March 9, 2026
概括
心力衰竭患者的血清水平显示出与死亡风险的U形关联. 最佳水平在1.6-2.5 mg/dL之间,低度和高度都有更高的风险.
科学领域:
- 心脏病学 心脏病学
- 临床化学 临床化学
- 公共卫生 公共卫生
背景情况:
- 对于心脏功能和节律调节至关重要.
- 心力衰竭患者容易出现缺乏症,影响心肌健康.
- 目前的血清的实验室参考范围可能无法识别慢性潜缺.
研究的目的:
- 为了研究血清水平与一年死亡率之间的关联,在一大群心力衰竭的美国退伍军人中.
- 为了确定降低心力衰竭患者死亡风险的最佳血清范围.
- 为了比较不同血清度的结果,包括标准参考范围以下和以上的血清度.
主要方法:
- 利用了来自627,349名退伍军人在2001年至2023年期间被诊断患有心力衰竭的门诊血清的数据.
- 将患者分类为血清的组:<1.6,1.6-1.7,1.8-2.0,2.1-2.3 (参考) 和>2.3 mg/dL.
- 采用考克斯模型和受限制的立方支线模型来评估一年死亡率和非线性关联的多变量调整的危险比率.
主要成果:
- 根据血清水平,所有原因的死亡率各不相同,在1.8-2.0和2.1-2.3 mg/dL组中观察到最低的死亡率.
- 与参考范围相比,调整后的危险比率表明,在<1.6 mg/dL和>2.3 mg/dL水平下,死亡风险明显高于参考范围.
- 限制性立方脊线分析揭示了一个U形的关联,死亡风险最低的发生在1.6-2.5 mg/dL之间.
结论:
- 美国退伍军人患有心力衰竭的血清水平与一年死亡率呈现出独立的U形关联.
- 最低的死亡风险在1.6-2.5毫克/分升范围内观察到,包括全球网络的最佳范围.
- 低磁血和高磁血都与心力衰竭患者的死亡风险增加有关.
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