在临床环境中用奥马利祖马布治疗后口服食物挑战
Hao Tseng1, Robert A Wood1, Jackie Isola1
1Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
概括
对大多数食物过敏 (FA) 患者来说,奥马利祖马布治疗使口服食物挑战 (OFC) 能够成功. 这种方法促进了过敏原食品的饮食引入,改善了患者的治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏和免疫学 过敏和免疫学
- 临床医学 临床医学
背景情况:
- 奥马利祖马布已被批准用于食物过敏 (FA) 治疗.
- 奥马利祖马布在FA中的临床有效性和结果需要进一步研究.
研究的目的:
- 为了评估口服食品挑战 (OFCs) 的结果,在接受OMALIZUMAB治疗的FA患者.
- 评估奥马利祖马布在临床环境中对FA管理的安全性和有效性.
主要方法:
- 对接受OFCs后omalizumab治疗的FA患者的回顾性图表审查.
- 在OFCs期间分析累积耐受食品剂量和不良事件.
主要成果:
- 对51名患者 (平均年龄为9岁) 进行了73次OFC,对牛奶,蛋和小麦过敏.
- 66%的患者在OFC期间成功消耗了≥6000mg的标过敏原.
- 过敏反应发生在45%的OFC中,使用抗胰岛素或上腺素进行管理.
- 在OFC后的92%情况下,允许通过饮食引入过敏性食物.
结论:
- 奥马利祖马布在临床环境中有效治疗FA.
- 在大多数FA患者的饮食中,奥马利祖马布有助于将过敏性食物引入饮食.
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