预防性血液静止治疗,以控制乳腺内膜活检期间的阴性出血 (PROTECT研究):多中心,随机化,单盲,安慰剂控制的研究
1Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo University, Ningbo, China; Health Science Center, Ningbo University, Ningbo, China.
预防性血静并没有显著降低内支气管活检期间的出血. 然而,冰冷的盐水显示了年轻患者 (<65岁) 降低出血的趋势,需要进一步调查.
科学领域:
- 肺部病理学 肺部病理学
- 胃肠病学 胃肠病学
- 干预性内镜检查是干预性的内镜检查.
背景情况:
- 胸膜内膜活检期间的阳性出血可能是严重的和危及生命的.
- 现有的指导方针建议使用预防性血静止剂,但临床证据仍然有限.
研究的目的:
- 为了评估预防性静血治疗在控制内支气管活检期间出血的疗效.
主要方法:
- 一个多中心的,随机的,安慰剂控制的试验,涉及462名参与者接受内支气管活检.
- 参与者被随机分配给接受上腺素,冰冷盐水或盐水 (安慰剂).
- 主要结局包括出血严重程度量表和视觉模拟量表.
主要成果:
- 与安慰剂相比,预防性血静并没有显著改善出血严重程度.
- 在65岁以下的患者使用冰冷盐水时,观察到减少出血的趋势 (RR 0.90 [95% CI 0.82-0.99],p=0.04).
- 预防性血液静止被证明是安全的.
结论:
- 预防性血液静止没有显示出与活检相关的出血有显著改善.
- 在较年轻的患者 (<65岁) 中注意到预防性血液静止的潜在益处,这表明需要进一步研究.
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