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双细菌长子物种双菌长子物种婴儿B8762通过微生物和代谢重编程调节婴儿肠肺轴

Rui Ma¹, Bo Jia¹, Xiangyang Zhang¹

¹Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, 010018, PR China.

Microbial pathogenesis

|March 9, 2026

概括

双细菌长子物种双菌长子物种补充infantis B8762改变了婴儿的肠道微生物群,丰富了有益的细菌并减少了病原体. 这种益生菌干预支持儿童的免疫调节和肠肺轴功能.

科学领域:

儿科微生物学儿科微生物学
肠肺轴研究的研究.
益生菌干预措施益生菌干预措施

背景情况:

呼吸道和胃肠道感染是儿童疾病的主要原因.
肠肺轴在调节感染易感性方面发挥着至关重要的作用.
特定的机制,通过它Bifidobacterium longum亚种. infantis B8762对感染的保护作用尚未完全理解.

研究的目的:

为了研究Bifidobacterium longum亚种的影响. infantis B8762补充剂对婴儿肠道微生物群的组成和功能.
阐明B8762在减少感染方面的观察到的临床疗效的机制基础.

主要方法:

一项随机,双盲,安慰剂控制的研究与115名6-12个月龄的婴儿进行.
便元基因组测序用于分析B8762补充剂4周后的微生物和功能变化.
统计分析评估了微生物多样性,种群丰度和代谢途径的变化.

主要成果:

双细菌长子物种双菌长子物种 infantis B8762显著改变了肠道微生物结构 (β-多样性,P < 0.05),但没有α-多样性.
干预丰富了有益的细菌 (例如,Bifidobacterium longum) 并减少了潜在的病原体 (例如,金黄色葡萄球菌).
B8762提高了关键代谢途径的调节,并增强了预测的免疫调节代谢物的产生,如丁酸盐.

结论:

双细菌长子物种双菌长子物种 infantis B8762调节儿科肠道微生物群,使其组成和代谢状况能够增强粘膜完整性和免疫调节.
这些发现为B8762对通过肠肺轴感染的保护作用提供了机械的见解.
这项研究支持使用B8762作为儿童肠肺轴健康的向益生菌.

关键词:

双细菌长子物种双菌长子物种婴儿婴儿 B8762 其他胃肠道感染胃肠道感染肠肺轴肠肺轴肠肺轴转基因组学是指转基因组学.呼吸道感染呼吸道感染

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