肺纤维化全球视角:流行病学,区域差异,护理差距和未来方向
Sahajal Dhooria1, Yoshikazu Inoue2,3, Kritarth Rathi4
1Department of Pulmonary Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India sahajal@gmail.com.
Thorax
|March 9, 2026
概括
肺纤维化 (PF) 影响全球人口的0.1%,其发病率正在上升. 通过改进诊断,治疗和意识来解决护理差距对于管理这一全球健康挑战至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 全球健康 全球健康
- 医学研究 医学研究
背景情况:
- 肺纤维化 (PF) 是一种与间歇性肺病 (ILD) 相关的疾病,影响全球人口的0.1%.
- 在15年内,对PF的研究增加了三倍,主要原因是特异性PF,结缔组织疾病相关的ILD,沙尔科毒症和过敏性肺炎.
- 这篇文章探讨了全球PF发病率,流行率,遗传学,诊断,治疗,护理差异以及最近的管理进展.
研究的目的:
- 探索与ILD相关的PF的发生率和流行率的全球变化.
- 审查目前的PF的诊断途径和治疗方法.
- 为了确定护理差距,并突出PF管理的最新进展.
主要方法:
- 对与ILD相关的PF的全球发病率和流行率数据的分析.
- 对诊断方法的审查,包括胸部成像,肺部组织学和专家评估.
- 探索治疗策略,护理差距和新兴治疗技术.
主要成果:
- 自1990年以来,全球每年与ILD相关的PF发生率增加了一倍多,现在估计每10万人口中有15到20例.
- PF发病率,流行率和频谱存在显著的区域差异,受遗传学,环境和诊断实践的影响.
- 大约30-60%的患者在1-2年内经历疾病进展,发达国家每年护理费用约为3万美元.
结论:
- 由于其多样化的临床表现和地理差异,PF对全球健康构成重大挑战.
- 解决护理缺口需要优先考虑新的药物开发,并扩大对PF的认识和服务.
- 像基因沉默,干细胞和基于纳米的药物输送等新兴技术有望改变未来的PF护理.
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