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在非人类灵长类动物中,强制性 flexor 协同作用的脊柱起源:对控制伸展的影响
Isabel S Glover1, Anne M E Baker1, John W Krakauer2,3,4
1Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
概括
卒中幸存者往往会产生 flexor 的协同作用. 这项研究发现脊髓电路,而不是大脑中心,偏差共收缩,建议针对脊髓的治疗以恢复中风.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 康复科学 康复科学 康复科学
背景情况:
- 脑卒中幸存者经常表现出 flexor 协同作用,其特点是肩膀绑架器和肘部 flexor 共同收缩,显著影响运动恢复.
- 负责产生这些协同运动的潜在神经机制在很大程度上仍未确定.
研究的目的:
- 为了研究负责在中风后产生 flexor 协同作用的神经基质.
- 为了确定更高的大脑中心或脊髓电路是否表现出对协同肌肉激活模式的偏见.
主要方法:
- 从运动皮层区域记录的神经元活动和子训练执行等比扭矩的网状形成.
- 在初级运动皮质,网状形成和脊髓中利用值微刺激来引起肌肉激活模式.
- 将唤起的肌肉共同收缩与观察到的 flexor 协同效应模式进行比较.
主要成果:
- 运动皮层和网状组织中的神经元都显示出一种偏向,即编码与 flexor 协同作用的正交直角的协同收缩.
- 然而,脊髓的微刺激经常引起与 flexor 协同作用一致的协同激活模式.
- 这些发现表明,较高的大脑中心并不是本质上倾向于产生协同模式.
结论:
- 原始的脊柱电路似乎局限于协同协同的协同激活,可能是为了运动而演变的.
- 在中风后观察到的 flexor 协同作用可能来自脊髓内部神经元活动,而不是更高的大脑中心.
- 准脊柱电路可能为缓解中风引起的运动缺陷提供一种新的治疗策略.
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