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Updated: Mar 11, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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Published on: October 25, 2018

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单细胞RNA测序揭示了基因表达异质性在不稳定,克隆衍生的CHO细胞系中基于人口的变化

Theodore W Peters1, Jake T Leinas1, Sofie O'Brien1

  • 1Molecular Cellular Technologies, Biotherapeutic Pharm. Sci., Pfizer Inc., Bothell, Washington, USA.

Biotechnology progress
|March 9, 2026
PubMed
概括

为蛋白质生产而设计的中国仓鼠卵巢细胞系往往会随着时间的推移而失去表达. 这项研究表明,基因表达的细胞异质性增加有助于细胞系制造中的这种不稳定性.

关键词:
在CHO细胞中.这就是ScRNAseqq.细胞衰老 细胞衰老克隆人群是指一个克隆人群.调节基因表达 调节基因表达代谢性压力是代谢性的压力.人口异质性 人口异质性单细胞转录组分析

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