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Updated: Apr 27, 2026

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小分子查识别了多发性骨髓瘤中细胞毒性内细胞网关联降解抑制剂

Erin M Kropp1,2, Sho Matono1,3, Olivia Y Wang1,3

  • 1Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, USA.

Cell death & disease
|March 10, 2026
PubMed
概括

奥马维洛克索隆 (RTA408) 抑制了多发性骨髓瘤 (MM) 中的与内分泌网膜相关的降解 (ERAD). 这种新的治疗策略显示,通过通过外部途径诱导亡,对抗抗蛋白酶抑制剂耐药的MM具有前途.

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After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
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