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Updated: Jul 23, 2026

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通过增加CCL2表达,PRMT6是启动和放大异型骨化中巨诱导的炎症所需的

Wenxiang Chu1, Weilin Peng1, Zhengqiang Wu1

  • 1Department of Orthopaedic surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.

Bone research
|March 10, 2026
PubMed
概括

蛋白质氨酸甲基转移酶6 (PRMT6) 通过促进巨细胞招募来驱动异型骨化 (HO) 中的炎症. 在受伤后早期准PRMT6可能会防止HO,同时保持组织修复.

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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