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Updated: Jun 27, 2026

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
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在运动皮层中对细胞类型特定的TDP-43病理的多模切剖析

Wolfgang P Ruf1,2, Julia K Kühlwein1, Laura Meier1

  • 1Department of Neurology, University Clinic, University of Ulm, Ulm, Germany.

Nature communications
|March 10, 2026
PubMed
概括

细胞质TDP-43病理主要影响大脑中的特定刺激神经元,导致细胞类型特定的转录变化. 了解这些独特的影响对于开发针对性治疗ALS/ALS-FTD至关重要.

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相关概念视频

Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.