在入侵性沙门氏菌Typhimurium ST313感染中具有独特的基因组轨迹
Chenghao Jia1,2, Haiyang Zhou2, Qianzhe Cao2
1School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou, China.
Nature communications
|March 10, 2026
概括
侵袭性非伤寒型沙门氏菌 (iNTS) 的演变是由人类因素驱动的,例如抗菌剂的使用. 一个高度耐药的亚系 (2.4) 出现,取代了较旧的亚系,需要加强对这种血液感染威胁的全球监测.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 公共卫生 公共卫生
背景情况:
- 侵袭性非伤寒型沙门氏菌 (iNTS) 疾病,特别是沙门氏菌Typhimurium序列型313 (ST313),是撒哈拉以南非洲的一个重大健康问题.
- ST313的传播动态和进化驱动因素仍然不明,这阻碍了有效的控制策略.
研究的目的:
- 分析INTS和ST313基因组的全面全球数据集.
- 确定关键的进化模式,抗菌素耐药性趋势,以及影响ST313传播和适应的因素.
主要方法:
- 编译和分析了11361个人类衍生的iNTS基因组和3115个ST313基因组的全球数据集.
- 采用了家族基因组分析来重建进化历史并识别遗传变化.
主要成果:
- 确定了一种高度抗微生物耐药的ST313亚系2.4和一个新兴的系4.
- 揭示了可能与人类运动相关的洲际传播模式,并在2.4.5亚系内确定了特定的抗菌素耐药性基因 (例如,blaOXA-1,blaCTX-M-15).
- 观察到的移动体驱动的耐药性变化与非洲1系的衰退相吻合,并确定了可能增强侵入性的遗传适应.
结论:
- 人为因素,包括抗微生物药物的使用和管理,显著塑造ST313的进化和耐药性.
- 加强全球监测对于监测iNTS的演变和传播至关重要,特别是对耐药ST313菌株的监测.
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