早餐时间改善夜间葡萄糖在怀孕中,由妊娠糖尿病复杂化
Hannah A Cunningham1, Lucy Ward2, Matthew P Butler1,3
1Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.
Diabetologia
|March 10, 2026
概括
当天早些时候吃饭可以改善妊娠期糖尿病 (GDM) 的孕妇的葡萄糖控制. 这种生活方式干预显示了降低夜间葡萄糖水平和提高整体24小时葡萄糖指标的潜力.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 时间生物学 时间生物学
背景情况:
- 孕期糖尿病 (GDM) 对孕妇和新生儿都有风险.
- 改变生活方式对于管理GDM和达到目标葡萄糖水平至关重要.
- 暂时饮食模式对GDM葡萄糖代谢的影响尚未完全理解.
研究的目的:
- 为了研究饮食时间对GDM患者24小时间歇性葡萄糖度的影响.
- 为了测试早晨早餐可以降低整体24小时葡萄糖水平的假设.
- 探索早期进食作为改善GDM血糖控制的潜在干预措施.
主要方法:
- 一个随机试验的二次分析,涉及患有GDM的孕妇 (n=71).
- 根据第一顿饭的时间,参与者被分为"早餐" (09:56前) 和"晚餐" (09:56后) 组.
- 连续血糖监测 (CGM) 数据使用共因子和线性模型进行分析,调整为共变量.
主要成果:
- "早餐"组与"晚餐"组相比,24小时葡萄糖节律的变化更早.
- 虽然白天的葡萄糖概况显示出白天时间的影响,但没有观察到任何显著的群体差异.
- 与"早餐"组相比",晚餐"组表现出明显更高的夜间葡萄糖水平.
结论:
- 餐饮时间,特别是采用早期的饮食模式,成为GDM管理的可行的生活方式干预措施.
- 早餐时间与改善夜间间间歇性葡萄糖控制有关.
- 这一发现支持了时间营养策略在优化GDM护理方面的潜力.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
5.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.3K
Pathophysiology of Diabetes
4.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.1K
Oral Hypoglycemic Agents: Glinides
789
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
789
Hypoglycemia and Glucagon
1.1K
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
1.1K
Dipeptidyl Peptidase 4 Inhibitors
836
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
836
Hormones Regulating Blood Glucose
7.9K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
7.9K


