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患有全身性红斑狼,接受腹腔透析的患者腹腔炎的危险因素

Ping Hsuan Kuo^1,2, Yi-Syuan Sun^1,3,4, Pu-Jun Fang²

¹Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

International journal of rheumatic diseases

|March 10, 2026

概括

腹膜透析 (PD) 的全身性红斑狼 (SLE) 患者面临更高的腹膜炎风险,特别是男性和服用胃酸抑制剂 (GAS) 或葡萄皮质皮质剂 (GC) 的患者. 然而,PD仍然是SLE患者安全的透析选择.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
类风湿病学类风湿病学
传染性疾病传染性疾病

背景情况:

对于接受腹腔透析 (PD) 的易受感染的系统性红斑狼 (SLE) 患者的药物治疗方案存在有限的数据.
腹膜炎是PD患者的重要并发症,特别是那些患有SLE等潜在疾病的患者.

研究的目的:

评估在PD的SLE患者中药物使用和腹膜炎风险之间的关联.
为了比较SLE患者和接受PD的非SLE对照者之间的腹膜炎率.

主要方法:

在2007-2023年期间对PD患者进行了回顾性研究.
倾向性得分匹配与46名SLE患者和46名非SLE对照进行了比较.
波松回归和时间依赖的考克斯比例危险模型分析了腹膜炎发病率和风险因素.

主要成果:

炎发病率在SLE患者中较高 (0.32次/患者年),而不是对照组 (0.25次/患者年).
在SLE患者中,独立的腹膜炎风险因素包括男性性别,胃酸抑制剂 (GAS) 和葡萄糖皮质类药物 (GC).
结果,如第一次腹膜炎的时间,导管切除和死亡率在各组之间是相似的.

结论:

腹腔透析 (PD) 是一种安全的透析方式,用于全身性狼 (SLE) 患者,其结果与非SLE对照结果相似.
在患有SLE的PD患者中,腹膜炎的风险可能因GAS,GC和男性性别而增加.
进一步研究优化SLE患者在PD的药物治疗方案是有必要的,以减轻腹膜炎的风险.

关键词:

胃酸抑制剂胃酸抑制剂葡萄糖皮质类药物腹膜透析是指腹膜透析.膜炎是一种膜炎.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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