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在儿科兄弟捐赠者中安全的外周干细胞采集:来自南印度的单中心体验

Deepti Sachan¹, Deepthi Krishna G¹, Vimal Kumar^2,3

¹Department of Transfusion Medicine, Dr. Rela Institute & Medical Centre, Chennai, India.

Pediatric transplantation

|March 10, 2026

概括

从儿科捐赠者采集周围血液干细胞 (PBSC) 是安全有效的,即使对于那些具有较低的捐赠者-接受者体重比率的人来说也是如此. 个性化策略和多学科的护理确保成功的造血干细胞移植 (HSCT).

科学领域:

血液学血液学血液学
儿科瘤学儿科瘤学
移植医学移植医学

背景情况:

外周血液干细胞 (PBSC) 采集是首选用于儿科全原血造干细胞移植 (HSCT) 由于更高的产量和更快的移植.
低体重儿科献血者面临的挑战包括少量血液,难以进入静脉和镇静风险,发展中国家的数据有限.

研究的目的:

评估南印度健康儿科兄弟捐赠者的PBSC采集的安全性和有效性.
评估Plerixa的使用对具有较低捐赠者-接受者体重比率 (DRWR) 的捐赠者的影响.

主要方法:

对35名健康的儿科兄弟捐赠者进行了回顾性分析,这些捐赠者接受了PBSC调动和收集.
捐赠者接受了颗粒细胞殖民地刺激因子 (G-CSF);在DRWR<0.75.5的情况下添加了Plerixafor.
使用Spectra Optia使用连续单核细胞采集进行的阿费雷西斯.

主要成果:

较高的供体体重与经过处理的血液体积增加以及产品白细胞/血小板数量增加相关.
与单独使用G-CSF相比,Plerixafor使用显著增加了外周血液中的CD34+计数和最终的CD34+产量.
所有手术都被很好地容忍,只有15.7%的采集中出现了轻微的,短暂的不良事件.

结论:

在儿科兄弟捐赠者中采集PBSC,包括那些低DRWR的捐赠者,是安全有效的.
个性化初始化策略和多学科护理对于儿科HSCT的成功结果至关重要.

关键词:

在PBSC的收藏中,PBSC的收藏是非常重要的.定制总理定制总理儿科干细胞供体儿童干细胞供体在plerixafor上使用.

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