对常见精神疾病的认知行为疗法后症状变化的全基因组协会研究
Julia Bäckman1, Olly Kravchenko1, Matthew Halvorsen1,2
1Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
概括
常见的遗传变异可能会对心理健康障碍的认知行为疗法 (CBT) 结果产生适度的影响. 虽然没有特定的遗传标记被确定,但需要进一步研究更大的样本来证实这些发现,以预测治疗反应.
科学领域:
- 精神病学和遗传学
- 行为科学 行为科学
- 临床心理学 临床心理学
背景情况:
- 认知行为疗法 (CBT) 是抑郁症,焦虑症和强迫症的主要治疗方法.
- 对CBT的治疗有效性在个体之间有很大差异.
- 对CBT结果的个体差异的预测因素尚未得到充分确立,这促使人们对遗传因素进行调查.
研究的目的:
- 调查常见的遗传变异,特别是单核酸多态 (SNP) 的贡献,以个人差异的症状变化后CBT.
- 探索遗传变异在预测常见精神疾病治疗结果中的作用.
主要方法:
- 全基因组关联研究 (GWAS) 针对3113名接受CBT治疗的MULTI-PSYCH和NORDiC群体的参与者进行.
- 分析的重点是症状变化,治疗前后症状严重程度和缓解状态.
- 基于SNP的遗传性被估计可以量化归因于常见遗传变异的变异比例.
主要成果:
- 没有任何特定的遗传变异达到预测症状变化的全基因组意义.
- 基于SNP的症状变化的遗传率估计为0.221 (SE = 0.123),这表明常见遗传变异的贡献很小.
- 对症状严重程度和缓解的二次分析也没有产生全基因组显著发现.
结论:
- 常见的遗传变异似乎在确定个体对CBT的反应中起到适度的作用.
- 需要更大的样本大小来实现更高的统计能力,以检测显著的遗传关联并完善遗传概率估计.
- 需要进一步的研究,以充分阐明CBT治疗结果背后的遗传结构.
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