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Updated: Mar 11, 2026

Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons
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生物发光探头用于多重复合RNA成像.

Erin B Fuller1, Kyle H Cole2, Lila P Halbers3

  • 1Department of Chemistry, University of California Irvine, Irvine, California 92617, United States.

Journal of the American Chemical Society
|March 10, 2026
PubMed
概括

研究人员开发了新的生物发光RNA探针,称为RNA灯,用于多重RNA检测. 这些探测器可以在没有激发光的情况下对活细胞内的多个RNA点进行敏感,连续的可视化.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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