湿疹和皮肤间的肌肉损伤:一个系统的审查和元分析 (审查)
T Ibrayeva1, A Iskakova2, T Algazina1
11Department of Dermatology and Cosmetology, Astana Medical University, Kazakhstan.
Georgian medical news
|March 10, 2026
概括
这项研究在湿疹患者中发现了皮肤间流失水分 (TEWL) 的显著差异,特别是在两性之间以及在19-44岁的成年人中. 管理TEWL可以帮助减轻湿疹的严重程度.
科学领域:
- 皮肤病学 皮肤病学
- 皮肤屏障研究研究
- 流行病学 流行病学
背景情况:
- 湿疹是一种慢性炎症性皮肤疾病,其特点是和.
- 皮肤屏障缺陷,导致水分减少和皮肤外流水分流失 (TEWL) 增加,是湿疹发展的关键因素.
- 这项研究调查了TEWL在湿疹患者的差异.
研究的目的:
- 分析表皮屏障功能的变化,特别是TEWL水平,在湿疹患者.
- 检查TEWL变异对湿疹严重程度的影响,考虑到性别差异.
主要方法:
- 进行了系统审查和元分析.
- 综合了来自15篇涉及1355例湿疹病例的文章的数据.
- 评估了TEWL得分与临床疾病严重程度之间的关联.
主要成果:
- 在男性和女性湿疹患者之间观察到TEWL水平的统计学上显著差异.
- 湿疹患者的TEWL升高从13.3%到76.7%不等.
- 与其他年龄组相比,年龄在19至44岁的人群中,TEWL升高的患病率更高 (59.8%).
结论:
- 湿疹中表皮屏障透性受损可能存在于其他皮肤疾病中.
- 改善TEWL水平显示出预防和减轻炎症性皮肤病的临床严重性的潜力.
相关概念视频
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Reticular Dermis
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Assessment of the Cardiovascular System II: Inspection
Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
Head and Neck
Head and Neck
Assessment of the Cardiovascular System III: Palpation
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
The Skin Microbiota
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...


