博西苏克拉法:一种天然的SGLT1/2抑制剂 来自Boscia senegalensis用于管理2型糖尿病
Bruno Eto1, Amal Elrherabi2, Fahd A Nasr3
1Laboratories TBC, Laboratory of Pharmacology, Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy University of Lille Lille France.
Food science & nutrition
|March 10, 2026
概括
来自 Boscia senegalensis 的 Boscisucrophage (BSP) 有效地降低了抗口服药物的2型糖尿病患者的血糖和HbA1c. 这项研究表明,BSP可能会作为双重SGLT1/SGLT2抑制剂,没有显著的不良影响.
科学领域:
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
- 代谢疾病 代谢疾病
背景情况:
- Boscia senegalensis是一种传统的非洲饥荒食物和药用植物.
- 它的种子被治疗师用来治疗高血糖症.
- 博斯基苏克拉法 (Boscisucrophage,简称BSP) 是一种商业化使用的博斯基亚塞内加拉属 (Boscia senegalensis) 提取物的剂型.
研究的目的:
- 为了评估BSP在2型糖尿病患者 (T2DM) 的疗效.
- 评估BSP对抗口服抗高血糖药物耐药的患者的影响.
- 探索BSP作为双重SGLT1/SGLT2抑制剂的潜在作用机制.
主要方法:
- 一个前性的,单中心的,开放的,单臂的干预研究.
- 参与了43名以前没有接受过治疗的患者和289名对口服抗糖尿病药物耐药的T2DM患者.
- 患者在12周内每天三次服用350毫克的BSP囊,通过血糖,HbA1c和尿液中的葡萄糖分泌监测结果.
主要成果:
- BSP显著降低了血糖和HbA1c水平.
- 观察到尿液中葡萄糖分泌量增加 (UGE).
- 观察到T2DM功能症状和副作用的缓解,没有显著的不良影响.
结论:
- 在对常规疗法耐药的T2DM患者中,BSP显示出管理血糖和HbA1c的潜力.
- 初步证据表明,SGLT1/SGLT2的双重抑制机制.
- 需要进一步的随机对照试验来验证.
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