在IVF/ICSI-ET患者中,影响妊娠结果的因素和预测算法
Chong Wang1, Xiao-Jing Yang1, Ying Feng1
1Department of Reproductive Medicine, Hangzhou Women's Hospital, Hangzhou, Zhejiang Province, People's Republic of China.
International journal of women's health
|March 10, 2026
概括
使用一种新的算法,可以预测体外受精/细胞内单个精子注射和胚胎移植 (IVF/ICSI-ET) 的临床妊娠结果. 关键因素包括男性年龄,AMH,孕激素水平和胚胎质量/数量,以提高试管婴儿成功率.
科学领域:
- 生殖医学 生殖医学
- 不孕症治疗 不孕症治疗
- 临床预测建模模型
背景情况:
- 试管受精/细胞内单种精子注射和胚胎移植 (IVF/ICSI-ET) 是一种常见的不孕症治疗方法.
- 预测临床妊娠结果对于优化治疗策略和患者咨询至关重要.
研究的目的:
- 确定影响IVF/ICSI-ET患者临床妊娠结果的关键因素.
- 在IVF/ICSI-ET周期中开发和验证临床怀孕的预测算法.
主要方法:
- 对1183个试管婴儿/ICSI-ET周期进行了回顾性分析.
- 后勤回归分析被用来识别重要的影响因素.
- 基于分层影响因素和定量评分,建立了一个预测算法.
主要成果:
- 男性年龄 (OR=0.965) 和hCG日的孕激素 (P) (OR=0.687) 与临床怀孕有负面关联.
- AMH (OR=1.085),高质量的胚胎 (OR=1.094) 和移植胚胎 (OR=2.218) 与临床怀孕有积极联系.
- 预测算法表现中等 (AUC=0.644),总分数为10或更高表明怀孕的可能性很高.
结论:
- 男性年龄,AMH,孕激素水平和胚胎质量/数量是试管婴儿/ICSI-ET成功的重要预测因素.
- 开发的预测算法为临床医生提供了一个更简单,更方便的工具来预测怀孕结果.
- 使用这种预测工具,可以改进个性化胚胎移植策略,以提高试管婴儿/ICSI-ET成功率.
相关概念视频
01:24In Vitro Fertilization
1.2K
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
1.2K
01:23Infertility in Males
633
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
633
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
515
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
515