反边语言网络集成预测并保护在叶切除后的命名下降
Karl-Heinz Nenning1,2, Karin Trimmel3, Lisa Bartha-Doering4,5
1Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, New York, USA.
Epilepsia
|March 10, 2026
概括
前叶切除 (ATLR) 可能会损害命名. 手术前的功能连接,特别是在右叶,预测命名衰退,有助于预测结果.
科学领域:
- 神经科学是一个神经科学.
- 神经外科 神经外科
- 的研究研究.
背景情况:
- 前叶切除 (ATLR) 有效地治疗耐药性叶 (TLE).
- ATLR存在语言缺陷的重大风险,特别是影响命名能力.
- 在ATLR之后预测语言结果仍然是一个临床挑战.
研究的目的:
- 研究ATLR对功能语言连接组的短期影响.
- 了解非主导半球在ATLR后语言功能中的作用.
- 为了确定ATLR之后命名障碍的预测因素.
主要方法:
- 功能磁共振成像 (fMRI) 用于评估语言网络连接.
- 44名TLE患者 (左24人,右20人) 接受了fMRI和ATLR前后的神经心理测试.
- 功能连接的变化与神经心理学表现相关.
主要成果:
- ATLR造成了广泛的功能连接变化,包括ipsilateral中断和反侧补偿.
- 左ATLR影响了半球间时连接;右ATLR影响了双边前部连接.
- 手术前的右叶连接预测了命名性能,机器学习模型改善了命名下降的预测.
结论:
- 右叶在支持以左ATLR命名方面发挥着至关重要的作用.
- 术前连接性评估可以提高术后语言结果的预测.
- 功能连接模式为神经外科手术后语言重组提供了宝贵的见解.
更多相关视频
13:12Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
Published on: August 12, 2019
46.6K
09:16Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping
Published on: March 24, 2023
2.1K
相关概念视频
01:28Lateralization
1.2K
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
1.2K
01:10Higher Mental Functions of the Brain: Language
4.0K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
4.0K
01:27Language and Cognition
912
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
912
01:05Cerebral Hemispheres
2.8K
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
2.8K
01:22Language Development
1.0K
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
1.0K