在3T磁力共振扫描上皮质大脑微发作的演变:风险因素和临床相关性
Jiannan Huang1, Christopher Chen2,3, Wei Ying Tan1
1Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
概括
在两年内,8.4%的患者出现新的皮质大脑微发作 (CMI),并与认知能力下降和痴呆风险有关. 它们的进化提供了对大脑血管健康的见解.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 血管痴呆症研究研究
背景情况:
- 大脑皮层微心脏病发作 (CMIs) 与认知障碍和痴呆症有关.
- 连续MRI上CMI的纵向演变还不清楚.
研究的目的:
- 通过连续MRI,研究五年来皮质CMI的演变.
- 确定CMI演变与认知功能和临床结果的关联.
主要方法:
- 490名记忆诊所患者的队列在基线和第二年接受了年度认知评估和MRI.
- 皮质CMI被评估为发生率,解决和纳入较大的心脏病发作.
- 记录了临床事件 (痴呆症,中风,死亡率).
主要成果:
- 到第二年,在8.4%的患者中观察到发生的皮质CMI.
- 在12名患者中,CMI得到了缓解,其中6名患者被纳入了更大的心脏病发作.
- 事件CMI与认知衰退,白质超强度进展和事件痴呆相关.
结论:
- 皮层CMI进化表明动态的大脑血管病理.
- 追踪CMI变化可能有助于识别患有认知衰退风险的个体.
- 皮质CMI代表了维护认知功能的潜在治疗标.
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