危急病患者抗生素相关腹的发生率和危险因素:系统性审查和元分析
Qianxin Wei1,2, Guangyu Lu3, Haiqing Diao1,2
1School of Nursing, Medical College of Yangzhou University, Yangzhou University, Yangzhou, China.
Journal of gastroenterology and hepatology
|March 10, 2026
概括
这次元分析发现,在重症患者中,抗生素相关性腹 (AAD) 的发生率为29%,Clostridioides difficile相关性腹 (CDAD) 的发生率为12%. 确定了关键的风险因素,可以帮助针对这些常见感染的预防策略.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素相关的腹 (AAD) 和Clostridioides difficile相关的腹 (CDAD) 是重症患者的重大并发症.
- 了解发病率和风险因素对于在重症监护病房 (ICU) 进行有效的预防和管理至关重要.
研究的目的:
- 在重症患者中量化评估AAD和CDAD的发病率.
- 确定与此脆弱人群中AAD和CDAD发展相关的独立风险因素.
主要方法:
- 通过搜索多个数据库 (科克兰图书馆,科学网,Embase,PubMed,CNKI,万芳) 进行了全面的元分析,直到2025年2月.
- 研究选择,数据提取和质量评估使用标准化工具 (纽卡斯尔-太华尺度,GRADE) 进行.
- 使用RevMan 5.4和Stata 15软件进行了统计分析.
主要成果:
- 整体AAD发病率为29% (95%CI:24%-35%),其中16个确定的危险因素包括年龄,男性性别,高血压,糖尿病和各种抗生素类别.
- 患有CDAD的发病率为12% (95%CI:7%-17%),确定的危险因素包括肠道营养,机械通风,卡巴胺抗生素,病和糖尿病.
- 发现像质子抑制剂这样的特定危险因素具有保护作用 (OR=0.56).
结论:
- 该研究提供了关于AAD和CDAD在重症患者中的发病率的关键定量数据.
- 鉴定的风险因素使得有针对性地识别高风险个体,以制定有针对性的预防策略.
- 这些发现支持制定基于证据的指导方针,用于重症监护机构的AAD和CDAD预防.
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