运动对2型糖尿病患者和健康成年人的同等急性抗炎作用:一项随机交叉研究
Yu-Min Huang1, Xianling Guo2,3, Jing-Jing Chen4
1Department of Sports Science, College of Education, Zhejiang University, Hangzhou, Zhejiang, China.
高灵敏度C反应蛋白 (hs-CRP) 区分了2型糖尿病 (T2D) 患者和健康的成年人. 急性炼会引起短暂的,细胞因子特异性的抗炎作用,而不是一般反应,为T2D提供个性化炼处方.
科学领域:
- 运动生理学 运动生理学
- 免疫学 免疫学 免疫学
- 代谢性疾病研究研究.
背景情况:
- 2型糖尿病 (T2D) 与慢性低度炎症有关.
- 识别炎症生物标志物和了解运动的抗炎作用对于T2D管理至关重要.
- 针对T2D建议基于指导方针的运动干预措施,但它们的急性炎症影响需要澄清.
研究的目的:
- 识别可以区分T2D患者与健康成年人的炎症生物标志物.
- 将急性抗炎反应与不同类型和强度的基于指南的运动进行比较.
- 探索基于炎症反应的个性化运动处方的潜力.
主要方法:
- 一个随机的三期交叉试验,涉及21名T2D患者和26名健康成年人.
- 参与者完成了三个运动试验:中等强度有氧运动,阻力和综合运动;不同强度的阻力运动;不同强度的综合运动.
- 在运动前,运动后和72小时后测量了hs-CRP,IL-6,IL-8,TNF-α和白细胞计数的循环水平.
主要成果:
- 与健康成年人相比,T2D患者的基线hs-CRP显著更高.
- 在大多数试验中,大多数炎症标志物,包括hs-CRP和白细胞计数,都没有被急性运动显著改变.
- 适度强度的抵抗运动在运动后立即显著降低了IL-8和TNF-α.
结论:
- 高灵敏度C反应蛋白 (hs-CRP) 作为一个关键的基线生物标志物,可以将受良好控制的T2D患者与健康个体区分开来.
- 急性炼引起的是短暂的,细胞因子特异性的抗炎效应,而不是普遍的反应.
- 介素-6 (IL-6) 动态受运动参数的影响,这表明在T2D中有个性化运动处方的潜力.
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