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慢性过量和衰老协同影响甲状腺激素的升高:在中国进行的一项前性20年后续研究
Xiaotong Gao1,2, Weiping Li1, Qingling Gu1
1Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, P.R. China.
概括
慢性过量会增加甲状腺刺激激素 (TSH) 水平,导致亚临床甲状腺功能低下症 (SCH). 衰老和状态相互作用影响TSH,持续的过量抑制非自身免疫个体的TSH上升.
科学领域:
- 内分泌学 在内分泌学.
- 甲状腺研究 甲状腺研究
- 公共卫生 营养 公共卫生 营养
背景情况:
- 慢性过量与血清铁激素 (TSH) 水平升高有关.
- 了解状态转换对TSH的长期影响至关重要.
研究的目的:
- 评估20年来过量过渡结果和老龄化对TSH水平的独立和相互作用影响.
- 为了研究摄入量的变化如何影响TSH和甲状腺健康随着时间的推移.
主要方法:
- 一项前性队列研究从1999年到2019年跟踪了中国北部的1176名参与者.
- 参与者根据尿度 (UIC) 过渡进行分类:持续充足 (SI-SI),过多到不足 (EI-DI),过多到充足 (EI-SI) 和持续过多 (EI-EI).
- 分析了TSH水平,亚临床甲状腺功能低下 (SCH) 患病率和甲状腺激素敏感性,这些都与状态和衰老有关.
主要成果:
- 20年后,与SI-SI组相比,过量组中阴性甲状腺抗体的参与者显示TSH升高和轻度SCH患病率增加.
- 持续过量组 (EI-EI) 呈现出最低的TSH增加程度.
- 衰老与稳定的TSH增加有关,衰老和状态过渡结果之间的显著相互作用调节了TSH上升;减轻过量促进了TSH升高,而持续的过量抑制了TSH.
- 在具有阳性甲状腺抗体的参与者中,持续的过量与SCH的更高患病率有关,包括严重病例.
结论:
- 由于慢性过量而导致的TSH升高不易通过减少摄入来逆转.
- 在非自身免疫个体中,衰老和状态相互作用,影响TSH水平.
- 过多的有助于轻度的SCH,并与更高的基线TSH相关.
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