儿童和青少年中颗粒物和心肺健康之间的负面和非线性关联:肥胖的调解效应
Feng Zhang1, Cun-Jian Bi2, Ya-Ru Guo2
1School of Sports Science and Engineering, ECUST-Chengxin Research Institute of Health Science and Engineering East China University of Science and Technology Shanghai China.
Journal of the American Heart Association
|March 10, 2026
概括
长期暴露于空气污染,特别是颗粒物,与儿童和青少年心肺呼吸能力 (CRF) 的降低有关. 肥胖部分解释了这种负面关联,强调了空气质量对年轻人的健康的影响.
科学领域:
- 环境健康 环境健康
- 儿科健康 儿科健康
- 心血管呼吸系统生理学
背景情况:
- 心血管健康 (CRF) 是儿童和青少年健康的关键指标.
- 暴露于颗粒物 (PM) 对肺部和心血管健康产生不利影响.
- 颗粒暴露与CRF及其介导因素之间的关系需要进一步调查.
研究的目的:
- 评估儿童和青少年长期暴露于颗粒物 (PM) 和CRF之间的关联.
- 调查脂肪在PM-CRF关系中的调解作用.
主要方法:
- 利用中国99995名儿童和青少年的全国性样本,通过多阶段随机集群采样.
- 从2013-2015年每天提取的空气动力学直径≤2.5和<10微米的PM2.5和PM10暴露数据.
- 评估CRF使用20米穿运行试验和通过腰部/身高比的脂肪度.
主要成果:
- 在PM2.5和PM10中增加10μg/m3与CRF显著下降有关 (分别为-0.12和-0.09毫升/公斤/分钟).
- 在PM水平和CRF (P<0.001) 之间观察到非线性暴露-反应关系.
- 腰部/身高比率介于PM暴露与CRF (P<0.001) 之间的关系的15.97% (PM2.5) 和16.15% (PM10).
结论:
- 长期暴露于颗粒物对年轻人的心肺呼吸能力有负面的,非线性关联.
- 肥胖,以腰高比表示,部分介于PM对CRF的有害影响.
- 建议进行进一步的队列研究来验证这些发现.
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