在两个学术医疗中心优化尿液药物查面板的影响
Grace K Mahowald1,2, Phillip Kang1, Peter R Chai2,3,4,5
1Department of Pathology, Mass General Brigham, Boston, MA, United States.
The journal of applied laboratory medicine
|March 10, 2026
概括
更新尿液药物查 (UDS) 面板,以反映当前的药物使用模式,提高了临床效用,减少了不必要的测试. 变化使实验室测试与药物使用趋势保持一致,标准化护理和优化资源配置.
科学领域:
- 临床化学 临床化学
- 毒理学 毒理学 毒理学
- 实验室医学 实验室医学
背景情况:
- 尿液药物查 (UDS) 面板往往不反映当前的药物使用模式,可能会限制临床效用.
- 对于实验室来说,经常审查和更新UDS面板组件是必不可少的.
研究的目的:
- 根据临床需要和当地流行病学,更新尿液药物查 (UDS) 专家组.
- 评估UDS小组变化对测试量,阳性率和临床订单实践的影响.
主要方法:
- 通过删除使用较少的药物 (例如,巴比图拉特,THC,甲) 并添加经常使用或关键物质 (例如,芬太尼,氧) 来修改UDS面板.
- 实施了针对特定药物类别 (例如,二胺类药物) 的改进分析.
- 分析了测试量,阳性率和临床医生订单行为的实施前后数据.
主要成果:
- 删除巴比酸盐,THC和甲导致单独订单的数量最小,这表明减少了不必要的测试.
- 芬太尼和 oxycodone 的测试显著增加 (分别是 8 倍和 3 倍).
- 改进的二胺剂测定导致两地阳性率增加16%.
结论:
- 更新UDS面板使实验室测试与当代药物使用模式保持一致,并提高临床效用.
- 修订后的UDS小组成功地减少了不必要的测试,并在医疗保健系统内标准化了护理.
- 变化表明有效适应不断变化的药物使用流行病学和改进的诊断准确性.
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