多药学,抗胆固醇负担和炎症与加速的生物衰老有关
Kai Wei1, Chun Chen1, Shuimei Sun2
1Department of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
Age and ageing
|March 10, 2026
概括
多药性和抗胆固醇负担加快了老年人的生物衰老,炎症起到了部分调解作用. 停止处方对于减少这些与衰老相关的风险至关重要.
科学领域:
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
- 生物医学科学 生物医学科学
背景情况:
- 多药性在老龄化人口中越来越令人担忧,与不利的健康结果有关.
- 多药和抗胆固醇负担对生物衰老的影响需要进一步研究.
- 系统性炎症作为药物使用和生物衰老之间的调解者的作用尚不清楚.
研究的目的:
- 调查多药和抗胆固醇负担与生物衰老标志物之间的关联.
- 评估系统性炎症对这些关联的调解作用.
- 检查潜在的连续途径,包括在衰老过程中的炎症.
主要方法:
- 来自美国65岁以上的成年人从国家健康和营养检查调查 (1999-2018) 的横截面数据的分析.
- 定义:多药性 (5-9种药物),超多药性 (≥10种药物),抗胆固醇负担 (抗胆固醇药物量表 - ADS).
- 生物衰老指标包括PhenoAge,KD-BioAge,AnthroAge,脆弱指数,端粒长度和α-Klotho. 这些都是生物衰老指标. 通过基于血细胞的指数评估的炎症. 统计分析包括加权回归和调解模型.
主要成果:
- 多药性 (35.0%) 和高多药性 (5.5%) 在10,556名老年人中普遍存在.
- 多药性和高抗胆固醇负担都与多个指标 (PhenoAge,KD-BioAge,AnthroAge,脆弱指数) 的加速生物衰老相关.
- 系统性炎症部分介导了多药/抗胆固醇负担和加速衰老 (PhenoAge,KD-BioAge) 之间的联系. 还观察到通过ADS和炎症的连续途径.
结论:
- 多药性和抗胆固醇负担与加速的生物衰老有显著的关联.
- 系统性炎症部分调解了这些关联,突出了它在衰老过程中的作用.
- 调查结果强调了抑郁药物的重要作用,以减轻与衰老相关的健康风险.
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